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Dr Theodoros Kyriakides

CONSULTANT NEUROLOGIST
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Dr Theodoros Kyriakides

MB.ChB , BSc (Hons) , FRCP (Lon)

 

CONSULTANT NEUROLOGIST

Specialisation: Neuromuscular, Multiple Sclerosis, General neurology


 

Research Activities

  • The study of the effect of complement C1Q on disease   phenotypeTTRMet30 peripheral neuropathy using a variety of transgenic mouse models.
  • The study of modifier genes in disease severity in Multiple sclerosis.
  • The study of Epigenetics in MS
  • The study of the epigenome in relation to MS disability progression
  • The study of reactive oxidative species in the pathophysiology of Duchenne muscular dystrophy.

 

Research Grants

1. Telethon Grant, A therapeutic trial of a Complement 5a receptor (C5aR) antagonist in a transgenic mouse model of Familial amyloidotic neuropathy Type I (TTRMet30Val) Support period: October 2014- Sept 2017, 60,000 Euros

 

2. Cyprus Research Foundation Grant, Principal Investigator ‘A study of modifier genes on disease severity in Multiple sclerosis’ Support period: May 2011- April 2014, 179,915 Euro

 

3.Cyprus Research Foundation Grant, Principal Investigator «A study of the role of complement C1Q in an animal model of Familial Amyloidotic neuropathy Type I». Support period: 1 April 2009-30 Sept 2011, 160,000 Euros

 

4. Cyprus Research Foundation Grant: «A study of modifier genes in Mitochondrial Encephalomyopathies», Support period: 1 September 2005- 1 January 2008, £ 56,200

 

5. Telethon Grant «Therapeutic trial of Melatonin and Trimetazidine in a Transgenic Mouse Model of Familial ALS», 14 January 2004 – 15 January 2006, £ 36,200

 

6. Cyprus Research Foudation Grant: «Cyprus Study of Familial Amyloidotic neuropathy Type I», 16   December 2002 – 15 June 2005,  £ 49,700

 

7. MDA Grant (USA), «Neuromuscular diseases in Eastern Mediterranean countries»,  1 July  2002 – 30 June  2005,  $192,180.

 

8. MDA Grant (USA)  “Neuromuscular diseases in Eastern  Mediterranean countries” Co-investigator , 1November 1994 – 31 October  1996,  US $ 204,400

 

9.  MDA Grant (USA) “Clinical and genetic studies of Charcot-Marie-Tooth type II and recessive forms”,  Co-investigator , 1 March 1996  – 30 June  1999, US $ 201,150

 

10.  MDA (AFM, France) “Molecular genetics of Charcot- Marie-Tooth type II”, Co- investigator  1996, FF 180,000

 

11. MDA Grant (USA) “Neuromuscular diseases in Eastern Mediterranean countries”, Co-investigator, 1 February 1997 – 30 June 1999,  US $ 158,000

 

12. MDA Grant (USA) “Neuromuscular diseases in eastern Mediterranean countries”, Co-investigator, 1 July 1999 – 30 June 2002, US $ 135,000

 

13. MDA Grant (USA)“Genetic studies in autosomal recessive hereditary motor neuronopathy and autosomal recessive inclusion body myopathy”, Co-investigator, 1July 1999 – 30 June  2002, US $ 180,000

 

Total number of publications: 78 articles, 5 chapters
Number of publications as first or last author : 36 articles, 5 chapters

 

PUBLICATIONS

1.    Kyriakides T, Langton Hewer R.
Hand contractures in Parkinson's Disease.  Journal of Neurology,
Neurosurgery and Psychiatry 1988; 51:1221-1223

 

2.    Kyriakides T, Aziz T Z, Torrens M J.
Postoperative recovery of third nerve Palsy due to posterior
communicating aneurysms. British Journal of Neurosurgery 1989; 3:109-112

 

3.    Anderson N A B, Kyriakides T, Pamphilon D H, Campbell M J.
Plasma exchange in Refsum's Disease; case report and review of the
literature. Transfusion Science 1989; 10(1):63-68

 

4.    Anderson N A B, Kyriakides T, Fergusson I T, Wallington T B.
Plasma Exchange in the Treatment of Guillain-Barre Syndrome:
Experience   in a Sub-regional Referral Unit.  Postgrad Med J 1991; 67:154-156.

 

5.    Kyriakides T, Hallam L A, Hockey A, Silberstein P, Kakulas B A.
“Angleman’s Syndrome"; A neuropathological study.  Acta
Neuropathological 1992; 83:675-678

 

6.    Kyriakides T, Silberstein J M, Jonpiputranich S, Silberstein P, Walsh P, Gubbay S,Kakulas B A. The significance of Type 1 fibre Predominance Muscle & Nerve 1993; 16:418-423

 

7.  Kyriakides T.
The use of multiple anti-dystrophin antibodies in Duchenne and Becker
muscular dystrophy. Journal of Neurology, Neurosurgery and Psychiatry
1993; 56 (10): 1137

 

8.  Alan S M, Kyriakides T, Lawden M, Newman PK.
Methylprednisolone in Multiple Sclerosis:  A comparison of Oral with
Intravenous Therapy at Equivalent High   Doses.  Journal of Neurology,
Neurosurgery and Psychiatry 1993; 56:1219-1220.

 

9. Kyriakides T, Gabriel G, Drousiotou A, Meznaric-Petrusa M, Middleton L
M. Dystrophinopathy presenting as congenital muscular dystrophy.
Neuromusc. Disord., 1994 4(4):387-392.

 

10. Kyriakides T, Silbert P, Kakulas B A.
Cerebral amyloid angiopathy and intracerebral haemorrhage with special
reference to the pons.  Clinical Neuropathology 1994; 13(2):71-76.

 

11. Kyriakides T, Drousiotou A.
No structural or biochemical evidence for mitochondrial cytopathy in a
case of alternating hemiplegia of childhood.  Annals of Neurology 1994;
36(5): 805-806.

 

12. Yamout BI, Kyriakides T, Tamim W, Drousiotou A.
Myalgia, neuromyopathy and internalized capillaries: A steroid responsive
syndrome.  Acta  Neurol  Scand 1995; 91:294-296.

 

13.  Christodoulou K, Kyriakides T, Hristova A H, Georgiou D M, Kalaydjieva
L, Yshpekova B, Ivanova T, Weber J L, Middleton L T.
Mapping of a distal form of spinal muscular atrophy with upper limb
predominance to chromosome 7p. Human Molecular Genetics, 1995; 4
(9):1629-1632.

 

14. Noguchi S, McNally E, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida
M,Yamamoto H, Bφnnemann C G, Gussoni E, Denton P H, Kyriakides T,
Middleton L T, Hentati F, Ben Hamida M, Nonaka I, Vance J M, Kunkel L
M, Ozawa E.
Mutations in the dystrophin-associated protein γ-sarcoglycan in
chromosome 13 muscular dystrophy.  Science, 1995; 270: 819-822.

 

15. Kyriacou K, Kassianides B, Hadjisavvas A, Middleton L, Kyriakides T.
The role of electron microscopy in the diagnosis of non-neoplastic muscle
diseases. Ultrastructural Pathology 1997; 21:243-252

 

16. Drousioutou A, Ioannou P, Georgiou T, Mavrikiou E, Christopoulos G,
Kyriakides T, Voyasianos M, Argyriou A, Middleton L.
Neonatal screening for Duchenne Muscular Dystrophy: a novel
semiquantitative application of bioluminescence test for creatine kinase in
a pilot national program in Cyprus. Genetic Testing 1998; 2: 55-60

 

17. Kyriakides T, Christodoulou K. Zamba E, Middleton L.
Hereditary motor neuronopathies; clinical, neurophysiological and genetic
aspects. Acta Myologica 1998; 2: 55-58
18. Kyriacou K, Mikellidou C, Hadjianastasiou, Middleton L, Panousopoulos A,

Kyriakides T
.  Ultrastructural Diagnosis of Mitochondrial Encephalomyopathies
revisited. Ultrastructural Pathology 1999; 23: 163-170

 

19. Middleton L, Christodoulou K, Mubaidin A, Zamba E, Tsingis M, Kyriakou
K, Abu-Shei Kh S, Kyriakides T, Neocleous V, Georgiou DM, El-Khateeb
M, Al- Qudah Al, Horany K.
Distal hereditary motor neuronopathy of the Jerash type. Annals New York
Academy Sciences 1999; 883: 65-68

 

20. Christodoulou K, Zambe E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik
S, El-Khatteb M, Kyriakou K, Kyriakides T, Al-Qudan AK, Middleton L.
A novel form of distal hereditary motor neuronopathy maps to
chromosome 9 p 21.1-12. Ann Neurol 2000, 48 (6): 877-84.

 

21. Zamba E, Christodoulou K, Al-Qudah AK, Horani K, Kyriakides T,
Middleton LT, Mubaidin A.  Autosomal recessive distal hereditary motor
neuropathies.  ACTA MYOLOGICA 2001: XX-1, 53-56.

 

22. Georgiou DM, Jedzejowska H, Ryniewicz B, Hansmanowa – Petrusewicz
I, Zamba E, Kyriakides T, Christodoulou K, Middleton LT.  Molecular
genetic studies in autosomal recessive Charcot-Marie Tooth disease.
ACTA  MYOLOGICA, XX-1, 35-38.
23. Kyriakides T, Marquez B, Panousopoulos A, Kyriacou E, Kyriacou K.
Amyloid myopathy:  evidence for mechanical injury to the sarcolemma.
Clinical Neuropathology 2002, 21, 145-148.

 

24. Georgiou DM, Zidar J, Korosec M, Middleton LT, Kyriakides T,
Christodoulou K.  A novel NF-L mutation Pro22 Ser is associated with
CMT2 in a large Slovenian family.  Neurogenetics 2002, 4(2): 93-96.

 

25. Zamba Papanicolaou E, Christodoulou K, Christodoulou C, Kyriakides T,
Middleton LT. Hereditary motor neuronopathies.  Revue Neurologic. 2002:
158(12): 1220-1224.

 

26.  Kleopas K, Papanicolaou E, Kyriakides T.
Lumbar compressive myelopathy presenting as segmental motor neuron
disease: Muscle Nerve – 2003 Jul ; 28 (1):69-73.

 

27. Papathanasiou E, Zamba-Papanicolaou E, Pantzaris M, Kyriakides T,
Papacostas S, Myrianthopoulou P, Pattichis C, Illiopoulos I, Piperidou.
A method of assessing the function of the vestibular system Electromyogr
Clin Neurophysiol. 2003 Oct-Nov; 43(7):399-408

 

28. Papathanasiou ES, Pantzaris M, Zamba-Papanicolaou E, Kyriakides T,
Kleopa KA,  liopoulos I, Piperidou C, Papacostas S.
Neurogenic vestibular evoked potentials in the diagnosis of multiple
sclerosis. Electromyogr Clin   Neurophysiol. 2004 Jul-Aug;
44(5):313-7.

 

29. Kyriakides T, Drousiotou A, Panasopoulou A, Hadjisavvas A, Zenios A,
Hadjigeorgiou G M, Kyriakou K.
A comparative morphological study in 33 cases of respiratory chain
encephalomyopathies.  Acta Myologica, 2003, 22 (2): 48-51.

 

30.  Kleopas K, Kyriakides T.
Lower lip dystonia: a new phenotypic variant of cranial
movement disorder. Movement Disorders 2004, 19 (6): 663-666.

 

31. Papathanasiou ES, Zamba-Papanicolaou E, Pantzaris M, Kleopa K,
Kyriakides T, Papacostas S, Pattichis C, Illiopoulos I, Piperidou C.
Neurogenic vestibular evoked potentials using a tone pip auditory
stimulus.  Electromyogr Clin Neurophysiol. 2004 April-May: 44(3), 167-73.

 

32. Kleopa KA, Georgiou DM, Nicolaou P, Koutsou P, Papathanasiou ES,
Kyriakides T, Christodoulou K.
A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy
with liability to pressure palsies and CMT1A phenotypes. Neurogenetics.
2004 Sep; 5(3):171-5.

 

33. Papathanasiou ES, Piperidou C, Iliopoulos I, Malekidou A, Katelari-
Theocharidou E, Kyriakides T, Kleopa KA, Papacostas SS.
Neurogenic  vestibular evoked potentials in three cases of vestibular
system dysfunction. Electromyogr Clin Neurophysiol. 2005 Jan-Feb;
45(1):39-45.

 

34. Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, Kyriakides T. Reversible
Inflammatory and vacuolar myopathy with vitamin E deficiency in celiac
disease. Muscle Nerve. 2005 Feb: 31(2):260-5.

 

35. Kyriacou K, Hadjisavvas A, Zenios A, Papacharalambous R, Kyriakides 

T
. Morphological methods in the diagnosis of mitochondrial
encephalomyopathies: the role of electron microscopy. Ultrastruct Pathol.
2005 May-Aug; 29(3-4):169-74.

 

36. Papathanasiou ES, Piperidou C, Pantzaris M, Iliopoulos I, Petsa M,
Kyriakides T, Kleopa KA, Papacostas SS. Vestibular symptoms and
signs are correlated with abnormal neurogenic vestibular evoked
potentials in   patients with multiple sclerosis.
Electromyogr Clin Neurophysiol. 2005 June; 45(4):195-201.

 

37.  Sivakumar K, Kyriakides T, Puls I, Nicolson GA, Funalot B, Antonellis A,
Sambuughin N, Christodoulou K, Beggs JL, Zamba-Papanicolaou E,
Ionasescu V, Dalakas MC, Green ED, Fischbeck KH, Goldfarb LG.
Phenotypic spectrum of disorders associated with glucyl-tRNA synthetase
mutations. Brain. 2005 Jul 13: 128:2304-14.

 

38.  Kleopa KA, Zamba-Papanicolaou E, Alevra X, Nicolaou P, Georgiou DM,
Hadjisavvas A, Kyriakides T, Christodoulou K.
Phenotypic and cellular expression of two novel connexin 32 mutations
causing CMT1X. Neurology.  2006 Feb; 66(3):396-402.

 

39. Kleopa KA, Drousiotou A, Mavrikiou E, Ormiston A, Kyriakides T.
Naturally occurring utrophin correlates with disease severity in Duchenne
muscular  dystrophy. Hum Mol Genet. 2006 May; 15(10),1623

 

40. Kyriakou K, Kyriakides T.
Mitochondrial encephalomyopathies: a review of the diagnostic methods with
emphasis on the role of electron  microscopy. J. Submicrosc. Cytol. Pathol.
2006 38 (2- 3): 201-208,

 

41. Pantelidou M, Zographos SE, Lederer CW, Kyriakides T, Pfaffl MW,
Santama N. Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiol Dis. 2007 Jun; 26(3):577-89

 

42 .Antoniades L., Eftychiou C., Kyriakides T., Christodoulou K., Katritsis DG
Malignant mutation in the lamin A/C gene causing progressive conduction system disease and early sudden death in a family with mild form of limb-girdle muscular dystrophy.J Interv. Card. Electrophysiol. 2007 Jun;19 (1):1-7.

 

Ten-year mortality from Creutzfeldt-Jakob disease in Cyprus. East Mediterr Health J. 2008 May-Jun; 14(3):715-9

 

44. Dardiotis E., Koutsou P., Papanicolaou E., Vonta I., Kladi D., Vassilopoulos D., Hadjigeorgiou G., Christodoulou K., Kyriakides T., Epidemiological, clinical and genetic study of Familial Amyloidotic Polyneuropathy in Cyprus.  Amyloid. 2009 Mar; 16(1):32-7

 

45. Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M, Hadjigeorgiou G, Cariolou M, Christodoulou K, Kyriakides T.

 

46. Kyriakides T, Angelini C, Schaefer J, Sacconi S, Siciliano G, Vilchez JJ,Hilton-Jones D European Federation of Neurological Societies. EFNS guidelines on the diagnostic approach  to pauci- or asymptomatic hyperCKemia. Eur J Neurol. 2010  Jun 1;17(6):767-73.

 

47. Nicolaou P, Zamba-Papanicolaou E, Koutsou P, Kleopa KA, Georghiou A, Hadjigeorgiou G, Papadimitriou A, Kyriakides T, Christodoulou K. Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics. Neuroepidemiology. 2010; 35(3):171-7

 

48. Kyriakides T, Papacostas S, Papanicolaou E, Bagdades E, Papathanasiou ES. Sleep hypoventilation syndrome and respiratory failure due to multifocal motor neuropathy with conduction block. Muscle Nerve. 2011 Apr; 43(4): 610-4.

 

49. Dardiotis E, Papathanasiou E, Vonta I, Hadjigeorgiou G,  Zamba-Papanicolaou E, Kyriakides T

 

50. Economides CP, Christodoulou L, Kyriakides T, Soteriades ES.
J Med Case Reports. 2011 Aug 26; 5: 419.
51. Kyriakides T, Pegoraro E, Hoffman EP, Piva L, Cagnin S, Lanfranchi G, GriggsRC, Nelson SF.
       1858-9.

 

52.C.I. Christodoulou, P.A. Kaplanis, V. Murray, M.S. Pattichis, C.S. Pattichis, T Kyriakides.
Multi-scale AM-FM analysis for the classification of surface electromyographic signals. Biomedical Signal Processing and Control, 2012; 7(3): 265-269

53. Fazekas F, Berger T, Fabjan TH, Ledinek AH, Jakab G, Komoly S, Kraus J, Kurča E, Kyriakides T, Lisý L, Milanov I, Panayiotou P, Jazbec SS, Taláb R, Traykov L, Turčáni P, Vass K, Vella N, Havrdová E.Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group. Wien Med Wochenschr. 2012 Aug; 162(15-16):354-366.

54.Votsi C, Zamba-Papanicolaou E, Georghiou A, Kyriakides T, Papacostas S, Kleopa KA, Pantzaris M, Christodoulou K. Investigation of SCA10 in the Cypriot population: further exclusion of SCA    dynamic repeat mutations. J Neurol Sci. 2012 Dec 15; 323(1-2):154-7

 

55. Kyriakides T, Angelini C, Schaefer J, Mongini T, Siciliano G, Sacconi S, Joseph J, Burgunder JM, Bindoff LA, Vissing J, de Visser M, Hilton-Jones D.
EFNS review on the role of muscle biopsy in the investigation of myalgia.
Eur J Neurol. 2013 Jul;20(7):997-1005

 

56. Fazekas F, Bajenaru O, Berger T, Fabjan TH, Ledinek AH, Jakab G, Komoly S, Kobys T, Kraus J, Kurča E, Kyriakides T, Lisý L, Milanov I, Nehrych T, Moskovko S, Panayiotou P, Jazbec SŠ, Sokolova L, Taláb R, Traykov L, Turčáni P, Vass K, Vella N, Voloshyná N, Havrdová E. How does fingolimod (gilenya(®)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis? Front Neurol. 2013 May, 1;4:10

 

57. Dardiotis E, Panayiotou E, Feldman ML, Hadjisavvas A, Malas S, Vonta I,
      Hadjigeorgiou G, Kyriakou K, Kyriakides T.
      Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration Neurosci Lett. 2013 Aug 26;548:170-5

 

58. Giannaki CD, Sakkas GK, Karatzaferi C, Hadjigeorgiou GM, Lavdas E,
      Kyriakides T, Koutedakis Y, Stefanidis I.
      Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study. BMC Nephrol. 2013 Sep 11;14:194.

 

59. Zisimopoulou P, Evangelakou P, Tzartos J, Lazaridis K, Zouvelou V, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Frenkian Cuvelier M, Stojkovic T, Debaets M, Losen M, Martinez-Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Tzartos SJ.
      A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis. J Autoimmun. 2014 Aug;52:139-45.
60. Papacostas SS, Papathanasiou ES, Kyriakides T, Pantzaris M.Cervical vestibular evoked myogenic potentials in cerebellar lesions. Otol Neurotol.  2014 Oct;35 (9):1633-7.
61. Tsonis AI, Zisimopoulou P, Lazaridis K, Tzartos J, Matsigkou E, Zouvelou V,
        Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-
        Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Behin A,
        Sharshar T, De Baets M, Losen M, Martinez-Martinez P, Kleopa KA,
        Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P,
        Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Casasnovas
        Pons C, Pitha J, Jakubíkova M,  Hanisch F, Tzartos SJ. MuSK autoantibodies in
         myasthenia gravis detected by cell  based assay - A multinational study. J
         Neuroimmunol. 2015 Jul 15;284:10-7.

 

62. Theodorou L, Nicolaou P, Koutsou P, Georghiou A, Anastasiadou V, Tanteles G, Kyriakides T, Zamba-Papanicolaou E, Christodoulou K. Genetic findings of Cypriot spinal muscular atrophy patients. Neurol Sci. 2015 Oct;36(10):1829-34

 

63. Petrou PP, Pantzaris M, Dionysiou M, Drousiotou A, Kyriakides T. Minimally symptomatic McArdle disease, expanding the genotype-phenotype spectrum. Muscle Nerve. 2015 Nov;52(5):891-5.

 

64. Tanteles GA, Nicolaou M, Patsia N, Delikurt-Tuncalp T, Spanou-Aristidou E, Leonidou E, Kyriakides T, Christophidou-Anastasiadou V. A rare cause of pruritic  Ichthyosis: Sjögren-Larsson syndrome in the first reported patients of Cypriot descent. Eur J Dermatol. 2015 Sep-Oct;25(5):495-6.

 

65. Obici L1, Kuks JB, Buades J, Adams D, Suhr OB, Coelho T, Kyriakides T; European Network for TTR-FAP (ATTReuNET). Recommendations for presymptomatic genetic testing and management of individuals at risk for hereditary transthyretin amyloidosis. Curr Opin Neurol. 2016 Feb;29 Suppl 1:S27-35.

 

66. Adams D; European Network for TTR-FAP (ATTReuNET). Optimizing the
Management of transthyretin familial amyloid polyneuropathy in Europe: early
diagnosis and effective care.Curr Opin Neurol. 2016 Feb;29 Suppl 1:S1-2.

 

67. Stergiou C, Lazaridis K, Zouvelou V, Tzartos J, Mantegazza R, Antozzi C,
Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T,
Vaknin A, Berrih-Aknin S, Behin A, Sharshar T, De Baets M, Losen M, Martinez-
Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk
A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A,
Gilhus NE, Casasnovas Pons C, Pitha J, Jakubíkova M, Hanisch F, Bogomolovas
J, Labeit D, Labeit S, Tzartos SJ. Titin antibodies in "seronegative" myasthenia
gravis--A new role for an old antigen J Neuroimmunol. 2016 Mar 15;292:108-15..

 

68. E. Panayiotou , R. Papacharalambous , A. Antoniou , G. Christophides ,
L. Papageorgiou , E. Fella , S. Malas , T. Kyriakides. Genetic background
modifies amyloidosis in a mouse model of ATTR neuropathy. Biochemistry and
Biophysics Reports Volume 8, December 2016, Pages 48–54

 

69. Panayiotou E, Fella E, Papacharalambous R, Malas S, Saraiva MJ, Kyriakides      

T.
  C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse
model of ATTRV30M amyloid neuropathy. PLoS One. 2017 Apr
13;12(4):e0175767. doi: 10.1371/journal.pone.0175767. eCollection 2017.

 

70. Dardiotis E, Panayiotou E, Provatas A, Christodoulou K, Hadjisavvas A,
Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM,

Kyriakides T
. Gene variants of adhesion molecules act as modifiers of disease
severity in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Apr 24;4(4):

 

71. Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E,
Kyriakides T, Zamba-Papanicolaou E. Epidemiology of Amyotrophic Lateral
Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study.
Neuroepidemiology. 2017;48(1-2):79-85. doi: 10.1159/000477126. Epub 2017
May 20.

 

72. Fella E, Sokratous K, Papacharalambous R, Kyriacou K, Phillips J, Sanderson
S,Panayiotou E, Kyriakides T. Pharmacological Stimulation of Phagocytosis
Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model
of  ATTR Neuropathy. Front Mol Neurosci. 2017 May 10;10:138.

 

73. Andreou S, Panayiotou E, Michailidou K, Pirpa P, Hadjisavvas A, El Salloukh A,
Barnes D, Antoniou A, Agathangelou P, Papastavrou K, Christodoulou K,
Tanteles GA, Kyriakides T. Epidemiology of ATTRV30M neuropathy in Cyprus
and the modifier effect of complement C1q on the age of disease onset.
Amyloid. 2018 Dec;25(4):220-226.

 

74. Kristen AV, Ajroud-Driss S, Conceição I, Gorevic P, Kyriakides T, Obici L.
Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-
mediated  amyloidosis. Neurodegener Dis Manag. 2019 Feb;9(1):5-23.

 

75. Buxbaum JN, Brannagan T 3rd, Buades-Reinés J, Cisneros E, Conceicao I,
Kyriakides T, Merlini G, Obici L, Plante-Bordeneuve V, Rousseau A, Sekijima Y,
Imai A, Waddington Cruz M, Yamada M. Transthyretin deposition in the eye in the
era of effective therapy for hereditary ATTRV30M amyloidosis. Amyloid. 2019 Jan
24:1-5
76. Dardiotis E, Panayiotou E, Siokas V, Aloizou AM, Christodoulou K, Hadjisavvas
A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T. Gene variants of
adhesion molecules predispose to MS: A case-control study. Neurol Genet. 2019
Jan 16;5(1):

BOOK CONTRIBUTIONS

 

1.   T. Kyriakides, C. Angelini, J. Schaefer, S. Sacconi, G. Siciliano, J. J. Vilchez  
D. Hilton-Jones (2012) Diagnostic Approach to Pauci- or Asymptomatic hyperCKemia"" in "European Handbook of Neurological Management, Volume 2, Second Edition" pp.279-286, Blackwell Publishing Ltd

 

2.   Kleopa K.A, Kyriakides T (2007) 
Cancer and the peripheral Nervous System" in "Baehring J, Piepmeier J(eds): Brain Tumors. Practical guide to Diagnosis and Treatment" pp.479-496, Informa healthcare, New York

 

3.   K Kyriacou and Kyriakides T (2002) 
"Diagnostic Electron Microscopy" in "Skeletal Muscle: Pathology, Diagnosis and Management of Disease" pp.459-470, Greenwich Medical media

 

4.   T.Kyriakides, L. Middleton (1996) 
Stroke from carotid bifurcation disease without premonitory transient ischaemic attacks" in "Cerebrovascular Ischamia Investigation and Management, ed, Louis R. Caplan, Edward G. Shifrin, Andrew N.Nicolaides, Wesley S. Moore" Pp.3-10, Med-Orion Publishing Company, London, Los Angeles, Nicosia

 

5.  T.Kyriakides, L. Middleton (1993)
The Magnitude of the Problem: Stroke from Carotid Bifurcation Disease without Premonitory Transient Ischaemic Attacks. Cerebral Revascularization In Berstein EF, Callow AD, Nicolaides A N, Shifrin E G (eds) pp 15-22 Med-Orion  Publishing Company, London, Los Angeles, Nicosia 1993;

Associated Hospitals / Clinics

Specialties

  • NEUROLOGIST

Experience

  • Consultant Neurologist  

    Professor of Neurology at University of Nicosia (http://www.unic.ac.cy/)

    25.2.2013

  • PREVIOUS POSITIONS  

    ,

    1.1.1987 - Neurology Registrar at Frenchy Hospital Bristol, UK 1.1.1988 - Neurolgy Registrar at Southmead Hospital Bristol, UK 1.1.1989 - Neurology Registrar at Newcastle General Hospital, UK 1.1.1990 - Neurology Registrar at Middleborough General Hospital, UK 1.1.1991 - Neuropathology Registrar Royal Perth Hospital Western Australia 15.3.1992 - Senior Neurologist & Director of Neuropathology Lab, at the Cyprus Institute of Neurology and Genetics (www.cing.ac.cy) 14.2.2012 - Professor at the Cyprus School of Molecular Medicine at the Cyprus Institute of Neurology and Genetics (www.cing.ac.cy/csmm)

  • PREVIOUS DUTIES AND RESPONSIBILITIES  

    PREVIOUS DUTIES AND RESPONSIBILITIES

    1992- 2019. Senior Neurologist & Director of Neuropathology Lab in charge of neuromuscular clinic and Director of Neuropathology Lab at the Cyprus Institute of Neurology and Genetics since 1992. He runs clinics for Duchenne muscular dystrophy, ALS and an Amyloid Neuropathy with the support of a multidisciplinary team. He also has general neurology clinic and sees a large number of Multiple sclerosis patients. He has access to a 20 bedded ward, and he directs a neuropathology lab which offers handles muscle and nerve biopsies. The neuropathology lab is the only of it kind in Cyprus and is a tertiary referral lab. The lab performs light and electron microscopy and a variety of immunohistochemistry. 2004-2013- Clinical coordinator of the Clinical Neuroscience section at the CING for ten years and his main task has been to oversee the optimal use of core facilities such the inpatient ward, the pharmacy and other administrative staff.

  • Other Professional Activities  

    Other Professional Activities

    Member of the Court of Examiners The Royal College of Surgeons of England Good Clinical Practice Certificate 11/6/2015 Chairperson of the EFNS task force on setting guidelines on how to investigate pauci/asymptomatic hyperCKemia Chairperson of the EFNS task force on setting guidelines on the role of muscle biopsy in the investigation of myalgia Chairperson of the Ministry of Health Committee on Multiple Sclerosis Chairperson of the Cyprus National Polio Certification Committee. Member of the Ministry of Health overseas patient sponsor committee Ad hoc reviewer for Muscle & Nerve 2009. Regular External Grant Reviewer for FTC Portugal.

Education

  • 1983 MB, ChB.   

    University of Bristol, U.K

  • 1980 B.Sc. (Honours) Physiology,   

    University of Bristol, U.K

  • 2003 FRCP (London)  

    (London)

  • 1986 ΜRCP   

    (UK)

Honours & Awards

  • Thomas Aubrey Memorial Priz  (January 1, 1982)

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