Dr Theodoros Kyriakides

Dr Theodoros Kyriakides

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Dr Theodoros Kyriakides

Dr Theodoros Kyriakides MB.ChB , BSc (Hons) , FRCP (Lon)

CONSULTANT NEUROLOGIST


'Αρθρα απο τον Δρ. Κυριακίδη:

Η διερεύνηση της Ασυμπτωματικής  ΥπερCKαιμίας

Μυαλγίες και η διερεύνησης τους


Personal Information

Personal Information

Fax:
22517900

Location Information

Postal Address:
Hippocrateon Private Hospital, 6-12 Psaron street
Town/Village:
Engomi
City Name:
Nicosia

Second Location

2nd Postal Ad.
Neurology Centre, Amaral 30, Corner of Kallipoleos street and Ifigenias 1, Lycavytos 1055, Nicosia

Awards - Qualifications

Awards & Distinctions:
Thomas Aubrey Memorial Prize 1982 
Certifications:
  • 1980 B.Sc. (Honours) Physiology, University of Bristol, U.K
  • 1983 MB, ChB. University of Bristol, U.K
  • 1986 ΜRCP (UK)
  •  2003 FRCP (London)

Educational Activities

  • Training psychiatry residents in neurology at CING 
  • Participant in Medical Genetics MSc course CING/University of Cyprus 
  • Organization  and participation  of workshops in the European Federation of Neurological Societies (EFNS)
  • Chairman of the European Federation of Neurological Societies (EFNS) Task force on setting guidelines on how to investigate pauci/asymptomatic hyperCKemia.
  • Chairman of the European Federation of Neurological Societies (EFNS) Task force on setting guidelines on role of Muscle biopsy in the investigation of myalgia
  • Senior Lecturer at St Georges Medical School (UNIC), Convenor of Life Control Module
  • Course organizer of the Neuroscience and Neurogenetics course at the Cyprus School of Molecular Medicine.
  • Programme organizer for Molecular Medicine
  • Lead for NeuroPlus  P Year St George’s Medical School University of London delivered by the University of Nicosia

Background

Practice Experience:
CURRENT POSITION
Consultant Neurologist
25.2.2013 - Professor of Neurology at University of Nicosia (http://www.unic.ac.cy/)

PREVIOUS POSITIONS
1.1.1987 - Neurology Registrar at Frenchy Hospital Bristol, UK
1.1.1988 - Neurolgy Registrar at Southmead Hospital Bristol, UK
1.1.1989 - Neurology Registrar at Newcastle General Hospital, UK
1.1.1990 - Neurology Registrar at Middleborough General Hospital, UK
1.1.1991 - Neuropathology Registrar Royal Perth Hospital Western Australia
15.3.1992 - Senior Neurologist & Director of Neuropathology Lab, at the Cyprus   
                  Institute of Neurology and Genetics (www.cing.ac.cy) 
14.2.2012 - Professor at the Cyprus School of Molecular Medicine at the Cyprus   
                  Institute of Neurology and Genetics (www.cing.ac.cy/csmm)


PREVIOUS DUTIES AND RESPONSIBILITIES

1992- 2019. Senior Neurologist & Director of Neuropathology Lab in charge of neuromuscular clinic and Director of Neuropathology Lab at the Cyprus Institute of Neurology and Genetics since 1992. He runs clinics for Duchenne muscular dystrophy, ALS and an Amyloid Neuropathy with the support of a multidisciplinary team. He also has general neurology clinic and sees a large number of Multiple sclerosis patients. He has access to a 20 bedded ward, and he directs a neuropathology lab which offers handles muscle and nerve biopsies. The neuropathology lab is the only of it kind in Cyprus and is a tertiary referral lab. The lab performs light and electron microscopy and a variety of   immunohistochemistry.

2004-2013- Clinical coordinator of the Clinical Neuroscience section at the CING  for  ten years and his main task has been to oversee the optimal use of core facilities such the inpatient ward, the pharmacy and other administrative staff.


Other Professional Activities
 
  • Member of the Court of Examiners The Royal College of Surgeons of England
  • Good Clinical Practice  Certificate 11/6/2015
  • Chairperson of the EFNS task force on setting guidelines on how to investigate pauci/asymptomatic hyperCKemia
  • Chairperson of the EFNS task force on setting guidelines on the role of muscle biopsy in the investigation of myalgia
  • Chairperson of the  Ministry of Health Committee on Multiple Sclerosis
  • Chairperson of the Cyprus National Polio Certification Committee.
  • Member of the Ministry of Health overseas patient sponsor committee 
  • Ad hoc reviewer for Muscle & Nerve 2009.
  • Regular External Grant Reviewer for FTC Portugal.

Doctor Specialties

NEUROLOGIST
Special Expertise:
Neuromuscular, Multiple Sclerosis, General neurology

Other Info

Publications & Presentations:

Research Activities
 
  • The study of the effect of complement C1Q on disease   phenotypeTTRMet30 peripheral neuropathy using a variety of transgenic mouse models.
  • The study of modifier genes in disease severity in Multiple sclerosis.
  • The study of Epigenetics in MS 
  • The study of the epigenome in relation to MS disability progression
  • The study of reactive oxidative species in the pathophysiology of Duchenne muscular dystrophy.


RESEARCH GRANTS

1. Telethon Grant, A therapeutic trial of a Complement 5a receptor (C5aR) antagonist in a transgenic mouse model of Familial amyloidotic neuropathy Type I (TTRMet30Val) Support period: October 2014- Sept 2017, 60,000 Euros

2. Cyprus Research Foundation Grant, Principal Investigator ‘A study of modifier genes on disease severity in Multiple sclerosis’ Support period: May 2011- April 2014, 179,915 Euro

3. Cyprus Research Foundation Grant, Principal Investigator «A study of the role of complement C1Q in an animal model of Familial Amyloidotic neuropathy Type I». Support period: 1 April 2009-30 Sept 2011, 160,000 Euros

4. Cyprus Research Foundation Grant: «A study of modifier genes in Mitochondrial Encephalomyopathies», Support period: 1 September 2005- 1 January 2008, £ 56,200

5. Telethon Grant «Therapeutic trial of Melatonin and Trimetazidine in a Transgenic Mouse Model of Familial ALS», 14 January 2004 – 15 January 2006, £ 36,200

6. Cyprus Research Foudation Grant: «Cyprus Study of Familial Amyloidotic neuropathy Type I», 16   December 2002 – 15 June 2005,  £ 49,700

7. MDA Grant (USA), «Neuromuscular diseases in Eastern Mediterranean countries»,  1 July  2002 – 30 June  2005,  $192,180.

8. MDA Grant (USA)  “Neuromuscular diseases in Eastern  Mediterranean countries” Co-investigator , 1November 1994 – 31 October  1996,  US $ 204,400 

9.  MDA Grant (USA) “Clinical and genetic studies of Charcot-Marie-Tooth type II and recessive forms”,  Co-investigator , 1 March 1996  – 30 June  1999, US $ 201,150

10.  MDA (AFM, France) “Molecular genetics of Charcot- Marie-Tooth type II”, Co- investigator  1996, FF 180,000

11. MDA Grant (USA) “Neuromuscular diseases in Eastern Mediterranean countries”, Co-investigator, 1 February 1997 – 30 June 1999,  US $ 158,000

12. MDA Grant (USA) “Neuromuscular diseases in eastern Mediterranean countries”, Co-investigator, 1 July 1999 – 30 June 2002, US $ 135,000  

13. MDA Grant (USA)“Genetic studies in autosomal recessive hereditary motor neuronopathy and autosomal recessive inclusion body myopathy”, Co-investigator, 1July 1999 – 30 June  2002, US $ 180,000


Total number of publications
78 articles, 5 chapters

Number of publications as first or last author 
36 articles, 5 chapters


Publications

1.    Kyriakides T, Langton Hewer R.  

     Hand contractures in Parkinson's Disease.  Journal of Neurology,    

     Neurosurgery and Psychiatry 1988; 51:1221-1223

 
2.    Kyriakides T, Aziz T Z, Torrens M J. 

     Postoperative recovery of third nerve Palsy due to posterior 

     communicating aneurysms. British Journal of Neurosurgery 1989; 3:109-112

 
3.    Anderson N A B, Kyriakides T, Pamphilon D H, Campbell M J.  

      Plasma exchange in Refsum's Disease; case report and review of the      

      literature. Transfusion Science 1989; 10(1):63-68

 
4.    Anderson N A B, Kyriakides T, Fergusson I T, Wallington T B.  

      Plasma Exchange in the Treatment of Guillain-Barre Syndrome:  

      Experience   in a Sub-regional Referral Unit.  Postgrad Med J 1991; 67:154-156.

                                                                                                                                                
5.    Kyriakides T, Hallam L A, Hockey A, Silberstein P, Kakulas B A. 

     “Angleman’s Syndrome"; A neuropathological study.  Acta 

      Neuropathological 1992; 83:675-678

                                                                                                                                                
6.    Kyriakides T, Silberstein J M, Jonpiputranich S, Silberstein P, Walsh P, Gubbay S,Kakulas B A. The significance of Type 1 fibre Predominance Muscle & Nerve 1993; 16:418-423

 
7.  Kyriakides T.                                         

    The use of multiple anti-dystrophin antibodies in Duchenne and Becker   

    muscular dystrophy. Journal of Neurology, Neurosurgery and Psychiatry 

    1993; 56 (10): 1137

 
8.  Alan S M, Kyriakides T, Lawden M, Newman PK. 

    Methylprednisolone in Multiple Sclerosis:  A comparison of Oral with 

    Intravenous Therapy at Equivalent High   Doses.  Journal of Neurology, 

    Neurosurgery and Psychiatry 1993; 56:1219-1220.

 
9. Kyriakides T, Gabriel G, Drousiotou A, Meznaric-Petrusa M, Middleton L 

      M. Dystrophinopathy presenting as congenital muscular dystrophy.  

      Neuromusc. Disord., 1994 4(4):387-392.

 
10. Kyriakides T, Silbert P, Kakulas B A.  

      Cerebral amyloid angiopathy and intracerebral haemorrhage with special 

      reference to the pons.  Clinical Neuropathology 1994; 13(2):71-76.
                                                                                                                                                                        

11. Kyriakides T, Drousiotou A.  

      No structural or biochemical evidence for mitochondrial cytopathy in a 

      case of alternating hemiplegia of childhood.  Annals of Neurology 1994; 

      36(5): 805-806.


12. Yamout BI, Kyriakides T, Tamim W, Drousiotou A.  

      Myalgia, neuromyopathy and internalized capillaries: A steroid responsive    

      syndrome.  Acta  Neurol  Scand 1995; 91:294-296.
 

13.  Christodoulou K, Kyriakides T, Hristova A H, Georgiou D M, Kalaydjieva 

        L, Yshpekova B, Ivanova T, Weber J L, Middleton L T.   

       Mapping of a distal form of spinal muscular atrophy with upper limb 

       predominance to chromosome 7p. Human Molecular Genetics, 1995; 4 

       (9):1629-1632.

 
14. Noguchi S, McNally E, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida 

      M,Yamamoto H, Bφnnemann C G, Gussoni E, Denton P H, Kyriakides T

      Middleton L T, Hentati F, Ben Hamida M, Nonaka I, Vance J M, Kunkel L 

      M, Ozawa E.

      Mutations in the dystrophin-associated protein γ-sarcoglycan in 

      chromosome 13 muscular dystrophy.  Science, 1995; 270: 819-822.


15. Kyriacou K, Kassianides B, Hadjisavvas A, Middleton L, Kyriakides T.

     The role of electron microscopy in the diagnosis of non-neoplastic muscle 

     diseases. Ultrastructural Pathology 1997; 21:243-252

 
16. Drousioutou A, Ioannou P, Georgiou T, Mavrikiou E, Christopoulos G, 

      Kyriakides T, Voyasianos M, Argyriou A, Middleton L.   

      Neonatal screening for Duchenne Muscular Dystrophy: a novel     

      semiquantitative application of bioluminescence test for creatine kinase in 

      a pilot national program in Cyprus. Genetic Testing 1998; 2: 55-60

                                                                                                                                           
17. Kyriakides T, Christodoulou K. Zamba E, Middleton L. 

      Hereditary motor neuronopathies; clinical, neurophysiological and genetic       

      aspects. Acta Myologica 1998; 2: 55-58


18. Kyriacou K, Mikellidou C, Hadjianastasiou, Middleton L, Panousopoulos A, 

      Kyriakides T
.  Ultrastructural Diagnosis of Mitochondrial Encephalomyopathies 

      revisited. Ultrastructural Pathology 1999; 23: 163-170


19. Middleton L, Christodoulou K, Mubaidin A, Zamba E, Tsingis M, Kyriakou 

      K, Abu-Shei Kh S, Kyriakides T, Neocleous V, Georgiou DM, El-Khateeb 

      M, Al- Qudah Al, Horany K.   

      Distal hereditary motor neuronopathy of the Jerash type. Annals New York    

      Academy Sciences 1999; 883: 65-68


20. Christodoulou K, Zambe E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik 

      S, El-Khatteb M, Kyriakou K, Kyriakides T, Al-Qudan AK, Middleton L.   

      A novel form of distal hereditary motor neuronopathy maps to 

      chromosome 9 p 21.1-12. Ann Neurol 2000, 48 (6): 877-84.


21. Zamba E, Christodoulou K, Al-Qudah AK, Horani K, Kyriakides T,  

     Middleton LT, Mubaidin A.  Autosomal recessive distal hereditary motor 

      neuropathies.  ACTA MYOLOGICA 2001: XX-1, 53-56.
 

22. Georgiou DM, Jedzejowska H, Ryniewicz B, Hansmanowa – Petrusewicz 

      I, Zamba E, Kyriakides T, Christodoulou K, Middleton LT.  Molecular 

       genetic studies in autosomal recessive Charcot-Marie Tooth disease. 

      ACTA  MYOLOGICA, XX-1, 35-38.


23. Kyriakides T, Marquez B, Panousopoulos A, Kyriacou E, Kyriacou K. 

     Amyloid myopathy:  evidence for mechanical injury to the sarcolemma.

     Clinical Neuropathology 2002, 21, 145-148.
 

24. Georgiou DM, Zidar J, Korosec M, Middleton LT, Kyriakides T

      Christodoulou K.  A novel NF-L mutation Pro22 Ser is associated with 

      CMT2 in a large Slovenian family.  Neurogenetics 2002, 4(2): 93-96.
 

25. Zamba Papanicolaou E, Christodoulou K, Christodoulou C, Kyriakides T,       

      Middleton LT. Hereditary motor neuronopathies.  Revue Neurologic. 2002:   

      158(12): 1220-1224.

 
26.  Kleopas K, Papanicolaou E, Kyriakides T

       Lumbar compressive myelopathy presenting as segmental motor neuron 

       disease: Muscle Nerve – 2003 Jul ; 28 (1):69-73.


27. Papathanasiou E, Zamba-Papanicolaou E, Pantzaris M, Kyriakides T

      Papacostas S, Myrianthopoulou P, Pattichis C, Illiopoulos I, Piperidou. 

      A method of assessing the function of the vestibular system Electromyogr 

      Clin Neurophysiol. 2003 Oct-Nov; 43(7):399-408


 28. Papathanasiou ES, Pantzaris M, Zamba-Papanicolaou E, Kyriakides T

       Kleopa KA,  liopoulos I, Piperidou C, Papacostas S. 

       Neurogenic vestibular evoked potentials in the diagnosis of multiple 

       sclerosis. Electromyogr Clin   Neurophysiol. 2004 Jul-Aug; 

       44(5):313-7. 


 29. Kyriakides T, Drousiotou A, Panasopoulou A, Hadjisavvas A, Zenios A,   

       Hadjigeorgiou G M, Kyriakou K.

       A comparative morphological study in 33 cases of respiratory chain 

       encephalomyopathies.  Acta Myologica, 2003, 22 (2): 48-51.


 30.  Kleopas K, Kyriakides T

        Lower lip dystonia: a new phenotypic variant of cranial   

        movement disorder. Movement Disorders 2004, 19 (6): 663-666.
 

 31. Papathanasiou ES, Zamba-Papanicolaou E, Pantzaris M, Kleopa K, 

       Kyriakides T, Papacostas S, Pattichis C, Illiopoulos I, Piperidou C. 

       Neurogenic vestibular evoked potentials using a tone pip auditory 

       stimulus.  Electromyogr Clin Neurophysiol. 2004 April-May: 44(3), 167-73. 
 

32. Kleopa KA, Georgiou DM, Nicolaou P, Koutsou P, Papathanasiou ES, 

      Kyriakides T, Christodoulou K.

      A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy 

      with liability to pressure palsies and CMT1A phenotypes. Neurogenetics. 

       2004 Sep; 5(3):171-5.
 

33. Papathanasiou ES, Piperidou C, Iliopoulos I, Malekidou A, Katelari-

      Theocharidou E, Kyriakides T, Kleopa KA, Papacostas SS. 

      Neurogenic  vestibular evoked potentials in three cases of vestibular 

      system dysfunction. Electromyogr Clin Neurophysiol. 2005 Jan-Feb; 

      45(1):39-45.


34. Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, Kyriakides T. Reversible 

     Inflammatory and vacuolar myopathy with vitamin E deficiency in celiac 

      disease. Muscle Nerve. 2005 Feb: 31(2):260-5. 
 

35. Kyriacou K, Hadjisavvas A, Zenios A, Papacharalambous R, Kyriakides 

      T
. Morphological methods in the diagnosis of mitochondrial 

      encephalomyopathies: the role of electron microscopy. Ultrastruct Pathol. 

      2005 May-Aug; 29(3-4):169-74.
 

36. Papathanasiou ES, Piperidou C, Pantzaris M, Iliopoulos I, Petsa M, 

      Kyriakides T, Kleopa KA, Papacostas SS. Vestibular symptoms and 

      signs are correlated with abnormal neurogenic vestibular evoked 

      potentials in   patients with multiple sclerosis.

      Electromyogr Clin Neurophysiol. 2005 June; 45(4):195-201. 


37.  Sivakumar K, Kyriakides T, Puls I, Nicolson GA, Funalot B, Antonellis A, 

       Sambuughin N, Christodoulou K, Beggs JL, Zamba-Papanicolaou E, 

       Ionasescu V, Dalakas MC, Green ED, Fischbeck KH, Goldfarb LG.         

       Phenotypic spectrum of disorders associated with glucyl-tRNA synthetase 

       mutations. Brain. 2005 Jul 13: 128:2304-14. 


38.  Kleopa KA, Zamba-Papanicolaou E, Alevra X, Nicolaou P, Georgiou DM, 

       Hadjisavvas A, Kyriakides T, Christodoulou K.

       Phenotypic and cellular expression of two novel connexin 32 mutations 

       causing CMT1X. Neurology.  2006 Feb; 66(3):396-402. 
 

39. Kleopa KA, Drousiotou A, Mavrikiou E, Ormiston A, Kyriakides T.

      Naturally occurring utrophin correlates with disease severity in Duchenne 

      muscular  dystrophy. Hum Mol Genet. 2006 May; 15(10),1623
 

40. Kyriakou K, Kyriakides T

     Mitochondrial encephalomyopathies: a review of the diagnostic methods with 

     emphasis on the role of electron  microscopy. J. Submicrosc. Cytol. Pathol. 

     2006 38 (2- 3): 201-208, 
 

41. Pantelidou M, Zographos SE, Lederer CW, Kyriakides T, Pfaffl MW, 

      Santama N. Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiol Dis. 2007 Jun; 26(3):577-89

 
42 .Antoniades L., Eftychiou C., Kyriakides T., Christodoulou K., Katritsis DG 
      Malignant mutation in the lamin A/C gene causing progressive conduction system    
      disease and early sudden death in a family with mild form of limb-girdle muscular   
     dystrophy.J Interv. Card. Electrophysiol. 2007 Jun;19 (1):1-7. 
 

      Ten-year mortality from Creutzfeldt-Jakob disease in Cyprus. 

      East Mediterr Health J. 2008 May-Jun; 14(3):715-9
 
 
44. Dardiotis E., Koutsou P., Papanicolaou E., Vonta I., Kladi D., Vassilopoulos D., 
 
       Hadjigeorgiou G., Christodoulou K., Kyriakides T., 
 
       Epidemiological, clinical and genetic study of Familial Amyloidotic    
       Polyneuropathy in Cyprus.  Amyloid. 2009 Mar; 16(1):32-7
 

45. Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M,   

        Hadjigeorgiou G, Cariolou M, Christodoulou K, Kyriakides T.

        polyneuropathy TTR Val30Met.
  J Neurol Sci. 2009 Sep 15; 284 (1-2): 158

 
46. Kyriakides T, Angelini C, Schaefer J, Sacconi S, Siciliano G, Vilchez JJ,Hilton-

      Jones D European Federation of Neurological Societies. EFNS guidelines on  

      the diagnostic approach  to pauci- or asymptomatic hyperCKemia. Eur J Neurol. 2010  Jun 1;17(6):767-73. 

 
47. Nicolaou P, Zamba-Papanicolaou E, Koutsou P, Kleopa KA, Georghiou A,
      Hadjigeorgiou G, Papadimitriou A, Kyriakides T, Christodoulou K.
      Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic
      characteristics. Neuroepidemiology. 2010; 35(3):171-7
 

48. Kyriakides T, Papacostas S, Papanicolaou E, Bagdades E, Papathanasiou ES.
      Sleep hypoventilation syndrome and respiratory failure due to multifocal motor
      neuropathy with conduction block. Muscle Nerve. 2011 Apr; 43(4): 610-4. 
 

49. Dardiotis E, Papathanasiou E, Vonta I, Hadjigeorgiou G,  Zamba-Papanicolaou 
      E, Kyriakides T 
     with myopathies. Acta Myol. 2011 Jun; 30(1):37-41.
 

50. Economides CP, Christodoulou L, Kyriakides T, Soteriades ES.
       J Med Case Reports. 2011 Aug 26; 5: 419.
 

51. Kyriakides T, Pegoraro E, Hoffman EP, Piva L, Cagnin S, Lanfranchi G, Griggs 
        RC, Nelson SF.
       1858-9. 
 

52.C.I. Christodoulou, P.A. Kaplanis, V. Murray, M.S. Pattichis, C.S. Pattichis, T Kyriakides.
      Multi-scale AM-FM analysis for the classification of surface electromyographic signals. Biomedical Signal Processing and Control, 2012; 7(3): 265-269
 

53. Fazekas F, Berger T, Fabjan TH, Ledinek AH, Jakab G, Komoly S, Kraus J, Kurča E, Kyriakides T, Lisý L, Milanov I, Panayiotou P, Jazbec SS, Taláb R, Traykov L, Turčáni P, Vass K, Vella N, Havrdová E.
      Fingolimod in the treatment algorithm of relapsing remitting multiple   
      sclerosis: a statement of the Central and East European (CEE) MS Expert Group. Wien Med Wochenschr. 2012 Aug; 162(15-16):354-366. 
 

54.Votsi C, Zamba-Papanicolaou E, Georghiou A, Kyriakides T, Papacostas S, Kleopa KA, Pantzaris M, Christodoulou K.      
      Investigation of SCA10 in the Cypriot population: further exclusion of SCA    dynamic repeat mutations. J Neurol Sci. 2012 Dec 15; 323(1-2):154-7
 
55. Kyriakides T, Angelini C, Schaefer J, Mongini T, Siciliano G, Sacconi S, Joseph J, Burgunder JM, Bindoff LA, Vissing J, de Visser M, Hilton-Jones D.
      EFNS review on the role of muscle biopsy in the investigation of myalgia. 
      Eur J Neurol. 2013 Jul;20(7):997-1005
 

56. Fazekas F, Bajenaru O, Berger T, Fabjan TH, Ledinek AH, Jakab G, Komoly S, Kobys T, Kraus J, Kurča E, Kyriakides T, Lisý L, Milanov I, Nehrych T, Moskovko S, Panayiotou P, Jazbec SŠ, Sokolova L, Taláb R, Traykov L, Turčáni P, Vass K, Vella N, Voloshyná N, Havrdová E. How does fingolimod (gilenya(®)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis? Front Neurol. 2013 May, 1;4:10
 

57. Dardiotis E, Panayiotou E, Feldman ML, Hadjisavvas A, Malas S, Vonta I,   
      Hadjigeorgiou G, Kyriakou K, Kyriakides T
      Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration Neurosci Lett. 2013 Aug 26;548:170-5
 

58. Giannaki CD, Sakkas GK, Karatzaferi C, Hadjigeorgiou GM, Lavdas E, 
      Kyriakides T, Koutedakis Y, Stefanidis I.
      Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study. BMC Nephrol. 2013 Sep 11;14:194. 
 
59. Zisimopoulou P, Evangelakou P, Tzartos J, Lazaridis K, Zouvelou V, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Frenkian Cuvelier M, Stojkovic T, Debaets M, Losen M, Martinez-Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Tzartos SJ.
      A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis. J Autoimmun. 2014 Aug;52:139-45
 
 
60. Papacostas SS, Papathanasiou ES, Kyriakides T, Pantzaris M.Cervical vestibular evoked myogenic potentials in cerebellar lesions. Otol Neurotol.  2014 Oct;35 (9):1633-7
 

61. Tsonis AI, Zisimopoulou P, Lazaridis K, Tzartos J, Matsigkou E, Zouvelou V,
        Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-    
        Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Behin A,  
        Sharshar T, De Baets M, Losen M, Martinez-Martinez P, Kleopa KA, 
        Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, 
        Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Casasnovas 
        Pons C, Pitha J, Jakubíkova M,  Hanisch F, Tzartos SJ. MuSK autoantibodies in 
         myasthenia gravis detected by cell  based assay - A multinational study. J 
         Neuroimmunol. 2015 Jul 15;284:10-7. 


62. Theodorou L, Nicolaou P, Koutsou P, Georghiou A, Anastasiadou V, Tanteles G, Kyriakides T, Zamba-Papanicolaou E, Christodoulou K. Genetic findings of Cypriot spinal muscular atrophy patients. Neurol Sci. 2015 Oct;36(10):1829-34


63. Petrou PP, Pantzaris M, Dionysiou M, Drousiotou A, Kyriakides T. Minimally symptomatic McArdle disease, expanding the genotype-phenotype spectrum. Muscle Nerve. 2015 Nov;52(5):891-5.


64. Tanteles GA, Nicolaou M, Patsia N, Delikurt-Tuncalp T, Spanou-Aristidou E, Leonidou E, Kyriakides T, Christophidou-Anastasiadou V. A rare cause of pruritic  Ichthyosis: Sjögren-Larsson syndrome in the first reported patients of Cypriot descent. Eur J Dermatol. 2015 Sep-Oct;25(5):495-6. 

 
65. Obici L1, Kuks JB, Buades J, Adams D, Suhr OB, Coelho T, Kyriakides T; European Network for TTR-FAP (ATTReuNET). Recommendations for presymptomatic genetic testing and management of individuals at risk for hereditary transthyretin amyloidosis. Curr Opin Neurol. 2016 Feb;29 Suppl 1:S27-35. 


66. Adams D; European Network for TTR-FAP (ATTReuNET). Optimizing the 

      Management of transthyretin familial amyloid polyneuropathy in Europe: early 

      diagnosis and effective care.Curr Opin Neurol. 2016 Feb;29 Suppl 1:S1-2. 

 

67. Stergiou C, Lazaridis K, Zouvelou V, Tzartos J, Mantegazza R, Antozzi C, 

     Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, 

     Vaknin A, Berrih-Aknin S, Behin A, Sharshar T, De Baets M, Losen M, Martinez-

    Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk

    A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, 

    Gilhus NE, Casasnovas Pons C, Pitha J, Jakubíkova M, Hanisch F, Bogomolovas 

    J, Labeit D, Labeit S, Tzartos SJ. Titin antibodies in "seronegative" myasthenia 

    gravis--A new role for an old antigen J Neuroimmunol. 2016 Mar 15;292:108-15..

 

68. E. Panayiotou , R. Papacharalambous , A. Antoniou , G. Christophides , 

     L. Papageorgiou , E. Fella , S. Malas , T. Kyriakides. Genetic background

     modifies amyloidosis in a mouse model of ATTR neuropathy. Biochemistry and 

     Biophysics Reports Volume 8, December 2016, Pages 48–54

 

 69. Panayiotou E, Fella E, Papacharalambous R, Malas S, Saraiva MJ, Kyriakides      

       T.
  C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse 

       model of ATTRV30M amyloid neuropathy. PLoS One. 2017 Apr 

       13;12(4):e0175767. doi: 10.1371/journal.pone.0175767. eCollection 2017.

 

70. Dardiotis E, Panayiotou E, Provatas A, Christodoulou K, Hadjisavvas A,

       Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, 

       Kyriakides T
. Gene variants of adhesion molecules act as modifiers of disease 

       severity in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Apr 24;4(4):

 

71. Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E, 

     Kyriakides T, Zamba-Papanicolaou E. Epidemiology of Amyotrophic Lateral 

     Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study. 

     Neuroepidemiology. 2017;48(1-2):79-85. doi: 10.1159/000477126. Epub 2017  

     May 20.

 

72. Fella E, Sokratous K, Papacharalambous R, Kyriacou K, Phillips J, Sanderson 

      S,Panayiotou E, Kyriakides T. Pharmacological Stimulation of Phagocytosis 

      Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model 

      of  ATTR Neuropathy. Front Mol Neurosci. 2017 May 10;10:138. 

 

73. Andreou S, Panayiotou E, Michailidou K, Pirpa P, Hadjisavvas A, El Salloukh A, 

     Barnes D, Antoniou A, Agathangelou P, Papastavrou K, Christodoulou K, 

     Tanteles GA, Kyriakides T. Epidemiology of ATTRV30M neuropathy in Cyprus 

     and the modifier effect of complement C1q on the age of disease onset. 

     Amyloid. 2018 Dec;25(4):220-226. 

 

74. Kristen AV, Ajroud-Driss S, Conceição I, Gorevic P, Kyriakides T, Obici L.

      Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin- 

      mediated  amyloidosis. Neurodegener Dis Manag. 2019 Feb;9(1):5-23. 

 

75. Buxbaum JN, Brannagan T 3rd, Buades-Reinés J, Cisneros E, Conceicao I, 

     Kyriakides T, Merlini G, Obici L, Plante-Bordeneuve V, Rousseau A, Sekijima Y, 

     Imai A, Waddington Cruz M, Yamada M. Transthyretin deposition in the eye in the 

     era of effective therapy for hereditary ATTRV30M amyloidosis. Amyloid. 2019 Jan 

      24:1-5


76. Dardiotis E, Panayiotou E, Siokas V, Aloizou AM, Christodoulou K, Hadjisavvas 

      A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T. Gene variants of 

      adhesion molecules predispose to MS: A case-control study. Neurol Genet. 2019 

      Jan 16;5(1):


Book Contributions:

1.   T. Kyriakides, C. Angelini, J. Schaefer, S. Sacconi, G. Siciliano, J. J. Vilchez  

D. Hilton-Jones (2012) Diagnostic Approach to Pauci- or Asymptomatic hyperCKemia"" in "European Handbook of Neurological Management, Volume 2, Second Edition" pp.279-286, Blackwell Publishing Ltd 


2.   Kleopa K.A, Kyriakides T (2007) 

Cancer and the peripheral Nervous System" in "Baehring J, Piepmeier J(eds): Brain Tumors. Practical guide to Diagnosis and Treatment" pp.479-496, Informa healthcare, New York


3.   K Kyriacou and Kyriakides T (2002) 

"Diagnostic Electron Microscopy" in "Skeletal Muscle: Pathology, Diagnosis and Management of Disease" pp.459-470, Greenwich Medical media

 
4.   T.Kyriakides, L. Middleton (1996) 

Stroke from carotid bifurcation disease without premonitory transient ischaemic attacks" in "Cerebrovascular Ischamia Investigation and Management, ed, Louis R. Caplan, Edward G. Shifrin, Andrew N.Nicolaides, Wesley S. Moore" Pp.3-10, Med-Orion Publishing Company, London, Los Angeles, Nicosia

 
5.  T.Kyriakides, L. Middleton (1993)

The Magnitude of the Problem: Stroke from Carotid Bifurcation Disease without Premonitory Transient Ischaemic Attacks. Cerebral Revascularization In Berstein EF, Callow AD, Nicolaides A N, Shifrin E G (eds) pp 15-22 Med-Orion  Publishing Company, London, Los Angeles, Nicosia 1993; 

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